Article

A multi-ancestry polygenic risk score for body mass index predicts longitudinal weight change

2025-07-17

Abstract excerpt

<h4>Background</h4> Persistent weight gain directly leads to obesity. Identifying individuals at risk for future weight gain is challenging, partly because associations with traditional clinical risk factors may be biased by confounding and reverse causation. Polygenic risk scores (PRS) provide a stable, lifelong measure of genetic predisposition to obesity. However, existing PRS have not been evaluated for their...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 602b9964-7eba-5836-b148-2d30a61c6624
DOI: 10.1101/2025.07.17.25331705

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A multi-ancestry polygenic risk score for body mass index predicts longitudinal weight changeDOI 10.1101/2025.07.17.25331705Read

A multi-ancestry polygenic risk score for body mass index predicts longitudinal weight changeSemantic proximity Read

Polygenic prediction of body mass index and obesity through the life course and across ancestries.Semantic proximity Read

Leveraging Multi-Ancestry Polygenic Risk Scores for Body Mass Index to Predict Antiretroviral Therapy-Induced Weight Gain.Semantic proximity Read

Polygenic risk predicts obesity in both white and black young adults.Semantic proximity Read

Impact of Genetic Predisposition to Obesity on Long-Term Maintenance of Modest Weight Loss in Postmenopausal Women.Semantic proximity Read

Dissecting the clinical relevance of polygenic risk score for obesity-a cross-sectional, longitudinal analysis.Semantic proximity Read

Quantifying factors that affect polygenic risk score performance across diverse ancestries and age groups for body mass indexSemantic proximity Read

Polygenic scores capture genetic modification of the adiposity-cardiometabolic risk factor relationship.Semantic proximity Read

Interaction of obesity polygenic score with lifestyle risk factors in an electronic health record biobank.Semantic proximity Read

Metabolic Polygenic Risk Scores for Prediction of Obesity, Type 2 Diabetes, and Related MorbiditiesSemantic proximity Read

Metabolic polygenic risk scores for prediction of obesity, type 2 diabetes, and related morbidities.Semantic proximity Read

Polygenic Risk Scores Expand to ObesitySemantic proximity Read