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Article

Efficient Estimation and Applications of Cross-Validated Genetic Predictions to Polygenic Risk Scores and Linear Mixed Models.

Journal of computational biology : a journal of computational molecular cell biology - 1 Apr 2020

Mefford Joel, Park Danny, Zheng Zhili, Ko Arthur, Ala-Korpela Mika, Laakso Markku, Pajukanta Päivi, Yang Jian, Witte John, Zaitlen Noah

Abstract excerpt

Large-scale cohorts with combined genetic and phenotypic data, coupled with methodological advances, have produced increasingly accurate genetic predictors of complex human phenotypes called polygenic risk scores (PRSs). In addition to the potential translational impacts of identifying at-risk individuals, PRS are being utilized for a growing list of scientific applications, including causal inference,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32077750
DOI: 10.1089/cmb.2019.0325
PMCID: PMC7185352

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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