A multi-ancestry polygenic risk score for body mass index predicts longitudinal weight change.

doi:10.1186/s13073-026-01741-8

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Article

A multi-ancestry polygenic risk score for body mass index predicts longitudinal weight change.

Genome medicine - 5 Aug 2026

Lu Tianyuan, Stalter Lily N, Lauer Kate V, Hanlon Bret M, Zhang Wenmin, Funk Luke M

Abstract excerpt

BACKGROUND: Identifying individuals at risk for future weight gain is challenging, partly because associations with traditional clinical risk factors may be biased by confounding and reverse causation. Polygenic risk scores (PRS) provide a stable, lifelong measure of genetic predisposition to obesity. However, existing PRS have not been evaluated for their association with longitudinal weight change in adulthood...

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Topics

Humans
Body Mass Index
Genetic Risk Score
Female
Genome-Wide Association Study
Genetic Predisposition to Disease
Male
Weight Gain
Obesity

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Risk Factors

Adult

Longitudinal Studies

Multifactorial Inheritance

Middle Aged

Source

Open in PubMed Open full text

Identifiers

PMID: 42693481
DOI: 10.1186/s13073-026-01741-8
PMCID: PMC13543510

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 10 Sept 2026.