Article

Stem cells actively suppress regenerative plasticity in human colon

2025-07-14

Abstract excerpt

Insights into intestinal stem cell functioning during homeostasis and repair have been predominantly derived from genetic mouse models. This is in stark contrast to the largely unexplored situation in the human gut, where the underlying mechanisms and stimuli that induce regeneration are poorly understood. Here, we developed genetic strategies to characterize fluorescently labelled LGR5 + stem cells in normal hum...

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Literature Corpus work: 2e7351a1-652d-5a3c-aa6e-9713c0d9bd91
DOI: 10.1101/2025.07.13.664589

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