Article
Dynamics of Proliferative and Quiescent Stem Cells in Liver Homeostasis and Injury.
Gastroenterology - 1 Oct 2017
Cao Wanlu, Chen Kan, Bolkestein Michiel, Yin Yuebang, Verstegen Monique M A, Bijvelds Marcel J C, Wang Wenshi, Tuysuz Nesrin, Ten Berge Derk, Sprengers Dave, Metselaar Herold J, van der Laan Luc J W, Kwekkeboom Jaap, Smits Ron, Peppelenbosch Maikel P, Pan Qiuwei
Abstract excerpt
BACKGROUND & AIMS: Adult liver stem cells are usually maintained in a quiescent/slow-cycling state. However, a proliferative population, marked by leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5), was recently identified as an important liver stem cell population. We aimed to investigate the dynamics and functions of proliferative and quiescent stem cells in healthy and injured livers. METHODS:...
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