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Article

Identification of stem cells in small intestine and colon by marker gene Lgr5.

Nature - 25 Oct 2007

Barker Nick, van Es Johan H, Kuipers Jeroen, Kujala Pekka, van den Born Maaike, Cozijnsen Miranda, Haegebarth Andrea, Korving Jeroen, Begthel Harry, Peters Peter J, Clevers Hans

Abstract excerpt

The intestinal epithelium is the most rapidly self-renewing tissue in adult mammals. It is currently believed that four to six crypt stem cells reside at the +4 position immediately above the Paneth cells in the small intestine; colon stem cells remain undefined. Lgr5 (leucine-rich-repeat-containing G-protein-coupled receptor 5, also known as Gpr49) was selected from a panel of intestinal Wnt target genes for its...

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PMID: 17934449
DOI: 10.1038/nature06196

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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