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Article

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration.

Nature - 14 Feb 2013

Huch Meritxell, Dorrell Craig, Boj Sylvia F, van Es Johan H, Li Vivian S W, van de Wetering Marc, Sato Toshiro, Hamer Karien, Sasaki Nobuo, Finegold Milton J, Haft Annelise, Vries Robert G, Grompe Markus, Clevers Hans

Abstract excerpt

The Wnt target gene Lgr5 (leucine-rich-repeat-containing G-protein-coupled receptor 5) marks actively dividing stem cells in Wnt-driven, self-renewing tissues such as small intestine and colon, stomach and hair follicles. A three-dimensional culture system allows long-term clonal expansion of single Lgr5(+) stem cells into transplantable organoids (budding cysts) that retain many characteristics of the original...

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Identifiers

PMID: 23354049
DOI: 10.1038/nature11826
PMCID: PMC3634804

Genes

RSPO1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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