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Article

Stem cell plasticity enables hair regeneration following Lgr5+ cell loss.

Nature cell biology - 1 Jun 2017

Hoeck Joerg D, Biehs Brian, Kurtova Antonina V, Kljavin Noelyn M, de Sousa E Melo Felipe, Alicke Bruno, Koeppen Hartmut, Modrusan Zora, Piskol Robert, de Sauvage Frederic J

Abstract excerpt

Under injury conditions, dedicated stem cell populations govern tissue regeneration. However, the molecular mechanisms that induce stem cell regeneration and enable plasticity are poorly understood. Here, we investigate stem cell recovery in the context of the hair follicle to understand how two molecularly distinct stem cell populations are integrated. Utilizing diphtheria-toxin-mediated cell ablation of Lgr5+...

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Identifiers

PMID: 28553937
DOI: 10.1038/ncb3535

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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