Foxl1-Expressing Mesenchymal Cells Constitute the Intestinal Stem Cell Niche

doi:10.1016/j.jcmgh.2015.12.004

Article

Foxl1-Expressing Mesenchymal Cells Constitute the Intestinal Stem Cell Niche

23 Dec 2015

Abstract excerpt

Background & Aims Intestinal epithelial stem cells that express leucine-rich repeat-containing G-protein coupled receptor 5 (Lgr5) and/or B cell specific Moloney murine leukemia virus integration site 1 (Bmi1) continuously replicate and generate differentiated cells throughout life. Previously, Paneth cells were suggested to constitute an epithelium-intrinsic niche that regulates the behavior of these stem cells....

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