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Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters.

Cell stem cell - 4 Feb 2016

Tetteh Paul W, Basak Onur, Farin Henner F, Wiebrands Kay, Kretzschmar Kai, Begthel Harry, van den Born Maaike, Korving Jeroen, de Sauvage Frederic, van Es Johan H, van Oudenaarden Alexander, Clevers Hans

Abstract excerpt

Intestinal crypts display robust regeneration upon injury. The relatively rare secretory precursors can replace lost stem cells, but it is unknown if the abundant enterocyte progenitors that express the Alkaline phosphate intestinal (Alpi) gene also have this capacity. We created an Alpi-IRES-CreERT2 (Alpi(CreER)) knockin allele for lineage tracing. Marked clones consist entirely of enterocytes and are all lost...

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Identifiers

PMID: 26831517
DOI: 10.1016/j.stem.2016.01.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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