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Characterization of radioresistant epithelial stem cell heterogeneity in the damaged mouse intestine

22 May 2020

Abstract excerpt

Abstract The small intestine has a robust regenerative capacity, and various cell types serve as “cells-of-origin” in the epithelial regeneration process after injury. However, how much each population contributes to regeneration remains unclear. Using lineage tracing, we found that Lgr5-expressing cell derivatives contained radioresistant intestinal stem cells (ISCs) crucial for epithelial regeneration in the...

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PMID: 32444673
DOI: 10.1038/s41598-020-64987-1

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