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Article

LRRK2 G2019S Mutated iPSC-Derived Endothelial Cells Exhibit Increased α-Synuclein, Mitochondrial Impairment, and Altered Inflammatory Responses.

International journal of molecular sciences - 29 Nov 2024

Sonninen Tuuli-Maria, Peltonen Sanni, Niskanen Jonna, Hämäläinen Riikka H, Koistinaho Jari, Lehtonen Šárka

Abstract excerpt

The blood-brain barrier (BBB) serves as an interface between the bloodstream and the central nervous system. It limits the movement of molecules and immune cells, regulates the entry of nutrients, and removes waste products from the brain. The dysfunction of the BBB has been identified in Parkinson's disease (PD) but the role of the BBB and endothelial cells (ECs) has not been well studied. LRRK2 G2019S mutation...

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Identifiers

PMID: 39684585
DOI: 10.3390/ijms252312874
PMCID: PMC11641647

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LRRK2 G2019S Mutated iPSC-Derived Endothelial Cells Exhibit Increased α-Synuclein, Mitochondrial Impairment, and Altered Inflammatory Responses.PMID 39684585Read ↗

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