Article

Vascularized midbrain assembloids show neuroinflammation and dopaminergic neuron vulnerability in Parkinson’s Disease

2025-08-07

Abstract excerpt

The use of micro-physiological systems has rapidly risen in the last years due to their translatability and complex cellular composition. Human midbrain-specific organoids contain neuroectoderm-derived cell types and are suitable for brain region-specific disease modeling. However, the lack of vasculature in these systems reduces oxygenation and nutrient supply. Furthermore, neurovascular interactions cannot be st...

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Literature Corpus work: 4599de84-95fe-5728-b6df-c3204ce75793
DOI: 10.1101/2025.08.06.668815

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