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Article

Global and Regional Changes in Perivascular Space in Idiopathic and Familial Parkinson's Disease.

Movement disorders : official journal of the Movement Disorder Society - 1 May 2021

Donahue Erin K, Murdos Amjad, Jakowec Michael W, Sheikh-Bahaei Nasim, Toga Arthur W, Petzinger Giselle M, Sepehrband Farshid

Abstract excerpt

BACKGROUND: The glymphatic system, including the perivascular space (PVS), plays a critical role in brain homeostasis. Although mounting evidence from Alzheimer's disease has supported the potential role of PVS in neurodegenerative disorders, its contribution in Parkinson's disease (PD) has not been fully elucidated. Although idiopathic (IPD) and familial PD (FPD) share similar pathophysiology in terms of protein...

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Identifiers

PMID: 33470460
DOI: 10.1002/mds.28473
PMCID: PMC8127386

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