Article

α-Synuclein Conformations in Plasma Distinguish Parkinson’s Disease from Dementia with Lewy Bodies

2024-05-08

Abstract excerpt

<h4> Abstract </h4> Spread and aggregation of misfolded α-synuclein (aSyn) within the brain is the pathologic hallmark of Lewy body diseases (LBD), including Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). While evidence exists for multiple aSyn protein conformations, often termed “strains” for their distinct biological properties, it is unclear whether PD and DLB result from aSyn strain difference...

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Literature Corpus work: d3f66727-2ac4-550a-bda5-ff36f96fa39c
DOI: 10.1101/2024.05.07.593056

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