Article

Microphysiological engineering of the capillary interface of substantia nigra dopaminergic neurons to study vascular alterations in Parkinson’s Disease

2025-05-18

Abstract excerpt

Parkinson’s Disease (PD) is primarily characterized by α-synuclein pathology, which manifests as intraneuronal inclusions, neuroinflammation, and neurodegeneration. However, emerging evidence also points to significant vascular impairments as a critical aspect of PD pathology, which remains largely underexplored due to the inability of traditional in vitro models to recapitulate such vascular changes. To address t...

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Literature Corpus work: 36cde6bb-065d-5bee-8a1d-f359a8388b40
DOI: 10.1101/2025.05.14.654131

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