Article

Genetic effects on longitudinal cognitive decline during the early stages of Alzheimer's disease

2021-04-16

Abstract excerpt

<h4>Background: </h4> Cognitive decline in early-stage Alzheimer’s disease (AD) may depend on genetic variability. <h4>Methods: </h4>: In the Swedish BioFINDER study, we used polygenic scores (PGS) (for AD, intelligence and educational attainment) to predict longitudinal cognitive change (measured by MMSE) over a mean of 4.2 years. We included 260 b-amyloid (Ab) negative cognitively unimpaired (CU) individuals, 12...

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Literature Corpus work: 2e357cff-db49-5d35-ba30-c291f8039f50
DOI: 10.21203/rs.3.rs-149163/v3

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