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Cumulative Genetic Risk and APOE ε4 Are Independently Associated With Dementia Status in a Multiethnic, Population-Based Cohort

5 Mar 2021

Abstract excerpt

Objective Alzheimer disease (AD) is a common and costly neurodegenerative disorder. A large proportion of AD risk is heritable, and many genetic risk factors have been identified. The objective of this study was to test the hypothesis that cumulative genetic risk of known AD markers contributed to odds of dementia in a population-based sample. Methods In the US population-based Health and Retirement Study (waves...

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PMID: 33688582
DOI: 10.1212/nxg.0000000000000576

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