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Article

Genetic effects on longitudinal cognitive decline during the early stages of Alzheimer's disease.

Scientific reports - 6 Oct 2021

Kumar Atul, Shoai Maryam, Palmqvist Sebastian, Stomrud Erik, Hardy John, Mattsson-Carlgren Niklas, Hansson Oskar

Abstract excerpt

Cognitive decline in early-stage Alzheimer's disease (AD) may depend on genetic variability. In the Swedish BioFINDER study, we used polygenic scores (PGS) (for AD, intelligence, and educational attainment) to predict longitudinal cognitive change (measured by mini-mental state examination (MMSE) [primary outcome] and other cognitive tests) over a mean of 4.2 years. We included 260 β-amyloid (Aβ) negative...

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Identifiers

PMID: 34615922
DOI: 10.1038/s41598-021-99310-z
PMCID: PMC8494841

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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