Article

Wnt activity reveals context-specific genetic effects on gene regulation in neural progenitors

2023-02-07

Abstract excerpt

Gene regulatory effects in bulk-post mortem brain tissues are undetected at many non-coding brain trait-associated loci. We hypothesized that context-specific genetic variant function during stimulation of a developmental signaling pathway would explain additional regulatory mechanisms. We measured chromatin accessibility and gene expression following activation of the canonical Wnt pathway in primary human neural...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2da3d0de-4ec4-5c71-8ec3-3888920773e4
DOI: 10.1101/2023.02.07.527357

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Wnt activity reveals context-specific genetic effects on gene regulation in neural progenitorsDOI 10.1101/2023.02.07.527357Read

Massively parallel assessment of gene regulatory activity at human cortical structure associated variantsSemantic proximity Read

Cell-type specific effects of genetic variation on chromatin accessibility during human neuronal differentiationSemantic proximity Read

Modern human changes in regulatory regions implicated in cortical development.Semantic proximity Read

Comprehensive multi-omics integration identifies differentially active enhancers during human brain development with clinical relevanceSemantic proximity Read

Cell-type-specific effects of genetic variation on chromatin accessibility during human neuronal differentiation.Semantic proximity Read

Revealing the transcription factor regulatory context of human specific cortical development using single-cell multi-omicsSemantic proximity Read

Spatiotemporal brain transcriptomics reveal risk gene hot-spots in major neuropsychiatric disorders.Semantic proximity Read

Comprehensive multi-omics integration identifies differentially active enhancers during human brain development with clinical relevance.Semantic proximity Read

Chromatin and gene-regulatory dynamics of the developing human cerebral cortex at single-cell resolution.Semantic proximity Read

Brain-trait-associated variants impact cell-type-specific gene regulation during neurogenesis.Semantic proximity Read

Genetic effects on brain traits impact cell-type specific gene regulation during neurogenesisSemantic proximity Read

Evolution is in the details: Regulatory differences in modern human and NeanderthalSemantic proximity Read