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Article

Comprehensive multi-omics integration identifies differentially active enhancers during human brain development with clinical relevance.

Genome medicine - 19 Oct 2021

Yousefi Soheil, Deng Ruizhi, Lanko Kristina, Salsench Eva Medico, Nikoncuk Anita, van der Linde Herma C, Perenthaler Elena, van Ham Tjakko J, Mulugeta Eskeatnaf, Barakat Tahsin Stefan

Abstract excerpt

BACKGROUND: Non-coding regulatory elements (NCREs), such as enhancers, play a crucial role in gene regulation, and genetic aberrations in NCREs can lead to human disease, including brain disorders. The human brain is a complex organ that is susceptible to numerous disorders; many of these are caused by genetic changes, but a multitude remain currently unexplained. Understanding NCREs acting during brain...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34663447
DOI: 10.1186/s13073-021-00980-1
PMCID: PMC8524963

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