Article

Evolution is in the details: Regulatory differences in modern human and Neanderthal

2020-09-04

Abstract excerpt

Transcription factor proteins play a critical role in the regulation of eukaryote gene expression via sequence- specific binding to genomic locations known as transcription factor binding sites. We studied sites of genomic variation between modern human and Neanderthal promoters. We detected significant differences in the binding affinities of 110 transcription factors to the promoters of 74 target genes. The tran...

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Literature Corpus work: 6a5fb895-eb58-5dad-9813-9874a748d804
DOI: 10.1101/2020.09.04.282749

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