Article

Massively parallel assessment of gene regulatory activity at human cortical structure associated variants

2025-02-08

Abstract excerpt

Genetic association studies have identified hundreds of largely non-coding loci associated with inter-individual differences in the structure of the human cortex, though the specific genetic variants that impact regulatory activity are unknown. We implemented a Massively Parallel Reporter Assay (MPRA) to measure the regulatory activity of 9,092 cortical structure associated DNA variants in human neural progenitor...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: af6658df-cae8-56da-99f7-784fcad60866
DOI: 10.1101/2025.02.08.635393

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Massively parallel assessment of gene regulatory activity at human cortical structure associated variantsDOI 10.1101/2025.02.08.635393Read

Wnt activity reveals context-specific genetic effects on gene regulation in neural progenitorsSemantic proximity Read

Massively parallel characterization of psychiatric disorder-associated and cell-type-specific regulatory elements in the developing human cortexSemantic proximity Read

Interrogating the Regulatory Function of HAQERs during Human Cortical DevelopmentSemantic proximity Read

Modern human changes in regulatory regions implicated in cortical development.Semantic proximity Read

Cell-type specific effects of genetic variation on chromatin accessibility during human neuronal differentiationSemantic proximity Read

The genetic architecture of the human cerebral cortex.Semantic proximity Read

BRAIN-MAGNET: A novel functional genomics atlas coupled with convolutional neural networks facilitates clinical interpretation of disease relevant variants in non-coding regulatory elementsSemantic proximity Read

Massively parallel functional screen identifies thousands of regulatory differences in human versus chimpanzee postcranial skeletal developmentSemantic proximity Read

Revealing the transcription factor regulatory context of human specific cortical development using single-cell multi-omicsSemantic proximity Read

A human-specific enhancer fine-tunes radial glia potency and corticogenesisSemantic proximity Read

3D Epigenomic Characterization Reveals Insights Into Gene Regulation and Lineage Specification During CorticogenesisSemantic proximity Read

Cell-type-specific 3D epigenomes in the developing human cortex.Semantic proximity Read