Article

Genetic effects on brain traits impact cell-type specific gene regulation during neurogenesis

2020-10-22

Abstract excerpt

Interpretation of the function of non-coding risk loci for neuropsychiatric disorders and brain-relevant traits via gene expression and alternative splicing is generally performed in bulk post-mortem adult tissue. However, genetic risk loci are enriched in regulatory elements active during neocortical differentiation, and regulatory effects of risk variants may be masked by heterogeneity in bulk tissue. Here, we m...

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Literature Corpus work: eb1c3ea6-3268-57b7-bfff-292480ec6080
DOI: 10.1101/2020.10.21.349019

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