Article
Cell-type-specific effects of genetic variation on chromatin accessibility during human neuronal differentiation.
Nature neuroscience - 1 Jul 2021
Liang Dan, Elwell Angela L, Aygün Nil, Krupa Oleh, Wolter Justin M, Kyere Felix A, Lafferty Michael J, Cheek Kerry E, Courtney Kenan P, Yusupova Marianna, Garrett Melanie E, Ashley-Koch Allison, Crawford Gregory E, Love Michael I, de la Torre-Ubieta Luis, Geschwind Daniel H, Stein Jason L
Abstract excerpt
Common genetic risk for neuropsychiatric disorders is enriched in regulatory elements active during cortical neurogenesis. However, it remains poorly understood as to how these variants influence gene regulation. To model the functional impact of common genetic variation on the noncoding genome during human cortical development, we performed the assay for transposase accessible chromatin using sequencing...
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