Article

Identifying the genetic basis of variation in cell behaviour in human iPS cell lines from healthy donors

2018-03-20

Abstract excerpt

Large cohorts of human iPSCs from healthy donors are potentially a powerful tool for investigating the relationship between genetic variants and cellular phenotypes. Here we integrate high content imaging, gene expression and DNA sequence datasets for over 100 human iPSC lines to identify the genetic basis of inter-individual variability in cell behaviour. By applying a dimensionality reduction approach, Probabili...

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Literature Corpus work: 2d97f569-5658-5f0b-b1fb-8b299d30d384
DOI: 10.1101/285627

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