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Article

Plating human iPSC lines on micropatterned substrates reveals role for ITGB1 nsSNV in endoderm formation.

Stem cell reports - 9 Nov 2021

Vickers Alice, Tewary Mukul, Laddach Anna, Poletti Martina, Salameti Vasiliki, Fraternali Franca, Danovi Davide, Watt Fiona M

Abstract excerpt

Quantitative analysis of human induced pluripotent stem cell (iPSC) lines from healthy donors is a powerful tool for uncovering the relationship between genetic variants and cellular behavior. We previously identified rare, deleterious non-synonymous single nucleotide variants (nsSNVs) in cell adhesion genes that are associated with outlier iPSC phenotypes in the pluripotent state. Here, we generated...

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Identifiers

PMID: 34678211
DOI: 10.1016/j.stemcr.2021.09.017
PMCID: PMC8581167

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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