Article

Population-scale proteome variation in human induced pluripotent stem cells

2018-10-11

Abstract excerpt

Realising the potential of human induced pluripotent stem cell (iPSC) technology for drug discovery, disease modelling and cell therapy requires an understanding of variability across iPSC lines. While previous studies have characterized iPS cell lines genetically and transcriptionally, little is known about the variability of the iPSC proteome. Here, we present the first comprehensive proteomic iPSC dataset, anal...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 37ceba7d-72bc-5d65-9ffd-1a77348c46d0
DOI: 10.1101/439216

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Population-scale proteome variation in human induced pluripotent stem cellsDOI 10.1101/439216Read

Population-scale proteome variation in human induced pluripotent stem cells.Semantic proximity Read

Common genetic variation drives molecular heterogeneity in human iPSCs.Semantic proximity Read

iPSCORE: A Resource of 222 iPSC Lines Enabling Functional Characterization of Genetic Variation across a Variety of Cell Types.Semantic proximity Read

Common genetic variation drives molecular heterogeneity in human IPSCsSemantic proximity Read

Systematic assessment of regulatory effects of human disease variants in pluripotent cellsSemantic proximity Read

Understanding the genetics behind complex human disease with large-scale iPSC collections.Semantic proximity Read

Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity.Semantic proximity Read

The iPSC proteomic compendiumSemantic proximity Read

Genetic dissection of the pluripotent proteome through multi-omics data integrationSemantic proximity Read

Identification of rare and common regulatory variants in pluripotent cells using population-scale transcriptomics.Semantic proximity Read

Humanity in a Dish: Population Genetics with iPSCs.Semantic proximity Read

Bridging population and cell: modelling complex diseases with human induced pluripotent stem cells.Semantic proximity Read