Article
Population-scale proteome variation in human induced pluripotent stem cells.
eLife - 10 Aug 2020
Mirauta Bogdan Andrei, Seaton Daniel D, Bensaddek Dalila, Brenes Alejandro, Bonder Marc Jan, Kilpinen Helena, Stegle Oliver, Lamond Angus I
Abstract excerpt
Human disease phenotypes are driven primarily by alterations in protein expression and/or function. To date, relatively little is known about the variability of the human proteome in populations and how this relates to variability in mRNA expression and to disease loci. Here, we present the first comprehensive proteomic analysis of human induced pluripotent stem cells (iPSC), a key cell type for disease...
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