Article
Genetics of growth rate in induced pluripotent stem cells.
Stem cell reports - 9 Jun 2026
Lee Brian N, Taylor Henry J, Cipriani Filippo, Narisu Narisu, Robertson Catherine C, Swift Amy J, Sinha Neelam, Yan Tingfen, Bonnycastle Lori L, Dale Nathan, Butt Annie, Parsaud Hemant, Semrau Stefan, Knowles Joshua W, Carcamo-Orive Ivan, D'Antonio-Chronowska Agnieszka, Frazer Kelly A, Biesecker Leslie G, Noggle Scott, Erdos Michael R, Paull Daniel, Collins Francis S, Taylor D Leland
Abstract excerpt
Induced pluripotent stem cells (iPSCs) enabled the generation of diverse cell types; however, certain fundamental biological properties, such as the genetic and epigenetic determinants of proliferation, remain poorly characterized. We quantified proliferation across 602 unique donors with a time-lapse imaging-based growth area under the curve (gAUC) phenotype and correlated gAUC with cell line gene expression and...
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