Article
Natural selection acting on complex traits hampers the predictive accuracy of polygenic scores in ancient samples
2024-09-11
Abstract excerpt
The prediction of phenotypes from ancient humans has gained interest due to its potential to investigate the evolution of complex traits. These predictions are commonly performed using polygenic scores computed with DNA information from ancient humans along with genome-wide association studies (GWAS) data from present-day humans. However, numerous evolutionary processes could impact the prediction of phenotypes fr...
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Identifiers and source
- Literature Corpus work
- 2d8e7713-c905-5dae-bdd9-7a09adbef64c
- DOI
- 10.1101/2024.09.10.612181