Polygenic prediction of human complex traits using ancient DNA.

doi:10.1016/j.gde.2025.102396

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Article

Polygenic prediction of human complex traits using ancient DNA.

Current opinion in genetics & development - 1 Dec 2025

Mathieson Iain

Abstract excerpt

Ancient DNA has revolutionized our understanding of human history and clarified many aspects of human evolution on a molecular level. In this article, I describe recent efforts to translate this into descriptions of phenotypic change over time and to predict phenotypes of ancient groups and individuals. I do not discuss the more challenging problem of distinguishing between adaptive and neutral evolution and...

Topics

Humans
DNA, Ancient
Multifactorial Inheritance
Phenotype
Evolution, Molecular

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Identifiers

PMID: 40886582
DOI: 10.1016/j.gde.2025.102396
PMCID: PMC12851537

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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