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Article

Population differentiation of polygenic score predictions under stabilizing selection.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 6 Jun 2022

Yair Sivan, Coop Graham

Abstract excerpt

Given the many small-effect loci uncovered by genome-wide association studies (GWAS), polygenic scores have become central to genomic medicine, and have found application in diverse settings including evolutionary studies of adaptation. Despite their promise, polygenic scores have been found to suffer from limited portability across human populations. This at first seems in conflict with the observation that most...

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PMID: 35430887
DOI: 10.1098/rstb.2020.0416
PMCID: PMC9014188

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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