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Article

Polygenic score accuracy in ancient samples: Quantifying the effects of allelic turnover.

PLoS genetics - 1 May 2022

Carlson Maryn O, Rice Daniel P, Berg Jeremy J, Steinrücken Matthias

Abstract excerpt

Polygenic scores link the genotypes of ancient individuals to their phenotypes, which are often unobservable, offering a tantalizing opportunity to reconstruct complex trait evolution. In practice, however, interpretation of ancient polygenic scores is subject to numerous assumptions. For one, the genome-wide association (GWA) studies from which polygenic scores are derived, can only estimate effect sizes for...

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PMID: 35522704
DOI: 10.1371/journal.pgen.1010170
PMCID: PMC9116686

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