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Article

Natural selection acting on complex traits hampers the predictive accuracy of polygenic scores in ancient samples.

American journal of human genetics - 3 Jul 2025

Añorve-Garibay Valeria, Huerta-Sanchez Emilia, Sohail Mashaal, Ortega-Del Vecchyo Diego

Abstract excerpt

The prediction of phenotypes from ancient humans has gained interest due to its potential to investigate the evolution of complex traits. These predictions are commonly performed using polygenic scores computed with DNA information from ancient humans along with genome-wide association study (GWAS) data from present-day humans. However, numerous evolutionary processes could impact these phenotypic predictions. In...

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Identifiers

PMID: 40499537
DOI: 10.1016/j.ajhg.2025.05.009
PMCID: PMC12256831

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