Article

Polygenic score accuracy in ancient samples: quantifying the effects of allelic turnover

2021-09-24

Abstract excerpt

Polygenic scores link the genotypes of ancient individuals to their phenotypes, which are often unobservable, offering a tantalizing opportunity to reconstruct complex trait evolution. In practice, however, interpretation of ancient polygenic scores is subject to numerous assumptions. For one, the genome-wide association (GWA) studies from which polygenic scores are derived, can only estimate effect sizes for loci...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2abfd355-5ffd-50b1-bb41-80c739a501bd
DOI: 10.1101/2021.09.21.461259

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Polygenic score accuracy in ancient samples: quantifying the effects of allelic turnoverDOI 10.1101/2021.09.21.461259Read

Polygenic score accuracy in ancient samples: Quantifying the effects of allelic turnover.Semantic proximity Read

Natural selection acting on complex traits hampers the predictive accuracy of polygenic scores in ancient samples.Semantic proximity Read

Natural selection acting on complex traits hampers the predictive accuracy of polygenic scores in ancient samplesSemantic proximity Read

Principled measures and estimates of trait polygenicitySemantic proximity Read

Population differentiation of polygenic score predictions under stabilizing selection.Semantic proximity Read

Principled measures and estimates of trait polygenicity.Semantic proximity Read

Reconstructing the history of polygenic scores using coalescent treesSemantic proximity Read

Polygenic adaptation after a sudden change in environmentSemantic proximity Read

Detecting polygenic adaptation in admixture graphsSemantic proximity Read

Signals of Human Polygenic Adaptation: Moving Beyond Single-Gene Methods and Controlling for Population-Specific Linkage DisequilibriumSemantic proximity Read

Detecting Polygenic Adaptation in Admixture Graphs.Semantic proximity Read

Polygenic prediction of human complex traits using ancient DNA.Semantic proximity Read