Article

Striking Departures from Polygenic Architecture in the Tails of Complex Traits

2024-11-20

Abstract excerpt

Understanding the genetic architecture of human traits is of key biological, medical and evolutionary importance[1]. Despite much progress, little is known about how genetic architecture varies across the trait continuum and, in particular, if it differs in the tails of complex traits, where disease often occurs. Here, applying a novel approach based on polygenic scores, we reveal striking departures from polygeni...

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Literature Corpus work: e951ba21-c0bd-5f25-b428-7781454f8fe8
DOI: 10.1101/2024.11.18.624155

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