Article
Astrocytes from old Alzheimer's disease mice are impaired in Aβ uptake and in neuroprotection.
Neurobiology of disease - 1 Dec 2016
Iram Tal, Trudler Dorit, Kain David, Kanner Sivan, Galron Ronit, Vassar Robert, Barzilai Ari, Blinder Pablo, Fishelson Zvi, Frenkel Dan
Abstract excerpt
In Alzheimer's disease (AD), astrocytes undergo morphological changes ranging from atrophy to hypertrophy, but the effect of such changes at the functional level is still largely unknown. Here, we aimed to investigate whether alterations in astrocyte activity in AD are transient and depend on their microenvironment, or whether they are irreversible. We established and characterized a new protocol for the...
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