Article

“Δ133p53α Protects Human Astrocytes from Amyloid-Beta Induced Senescence and Neurotoxicity”

2021-05-18

Abstract excerpt

<h4>ABSTRACT</h4> Cellular senescence is an important contributor to aging and age-related diseases such as Alzheimer’s disease (AD). Senescent cells are characterized by a durable cell proliferation arrest and the acquisition of a proinflammatory senescence-associated secretory phenotype (SASP), which participates in the progression of neurodegenerative disorders. Clearance of senescent glial cells in an AD mous...

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Literature Corpus work: ca208e56-9dc0-56d9-a57a-da318da0ac5c
DOI: 10.1101/2021.05.17.444544

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