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Article

Radiotherapy and radio-sensitization in H3K27M -mutated diffuse midline gliomas.

CNS neuroscience & therapeutics - 1 Jul 2023

Liu Chao, Kuang Shuwen, Wu Lei, Cheng Quan, Gong Xuan, Wu Jun, Zhang Longbo

Abstract excerpt

BACKGROUND: H3K27M mutated diffuse midline gliomas (DMGs) are extremely aggressive and the leading cause of cancer-related deaths in pediatric brain tumors with 5-year survival <1%. Radiotherapy is the only established adjuvant treatment of H3K27M DMGs; however, the radio-resistance is commonly observed. METHODS: We summarized current understandings of the molecular responses of H3K27M DMGs to radiotherapy and...

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Identifiers

PMID: 37157237
DOI: 10.1111/cns.14225
PMCID: PMC10324372

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