Article

Inhibition of H3K27M-enhanced ATM signaling increases radiation efficacy in diffuse midline glioma

2024-11-03

Abstract excerpt

<h4>ABSTRACT</h4> H3K27-altered diffuse midline glioma (DMG) is an aggressive and treatment-resistant form of pediatric high-grade glioma (pHGG). The disease is defined by point mutations in histone H3 that convert lysine 27 to methionine (termed H3K27M), resulting in genome-wide epigenetic changes that drive tumorigenesis. While radiation therapy is the standard of care, subsequent recurrence, often within the h...

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Literature Corpus work: eb9dfd88-666c-5770-9c4a-d3448015e28a
DOI: 10.1101/2024.11.01.621526

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