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<i>Ataxia-telangiectasia mutated</i> ( <i>Atm</i> ) disruption sensitizes spatially-directed H3.3K27M/TP53 diffuse midline gliomas to radiation therapy

2023-10-20

Abstract excerpt

<h4>Summary</h4> Diffuse midline gliomas (DMGs) are lethal brain tumors characterized by p53-inactivating mutations and oncohistone H3.3K27M mutations that rewire the cellular response to genotoxic stress, which presents therapeutic opportunities. We used RCAS/tv-a retroviruses and Cre recombinase to inactivate p53 and induce K27M in the native H3f3a allele in a lineage- and spatially-directed manner, yielding p...

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Literature Corpus work
d3eb9139-2933-58a4-9234-48737881bcc4
DOI
10.1101/2023.10.18.562892
Open publication

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