Article

H3K27M diffuse midline glioma is homologous recombination defective and sensitized to radiotherapy and NK cell-mediated antitumor immunity by PARP inhibition

2024-08-27

Abstract excerpt

<h4>Background</h4> Radiotherapy (RT) is the primary treatment for diffuse midline glioma (DMG), a lethal pediatric malignancy defined by histone H3 lysine 27-to-methionine (H3K27M) mutation. Based on the loss of H3K27 trimethylation producing broad epigenomic alterations, we hypothesized that H3K27M causes a functional double-strand break (DSB) repair defect that could be leveraged therapeutically with PARP inhi...

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Literature Corpus work: 5b5d7e8d-8912-5da8-ab36-9650aeb9ab0d
DOI: 10.1101/2024.08.26.609803

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