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Article

Radio-Resistance and DNA Repair in Pediatric Diffuse Midline Gliomas

30 Sept 2020

Abstract excerpt

Malignant gliomas (MG) are among the most prevalent and lethal primary intrinsic brain tumors. Although radiotherapy (RT) is the most effective nonsurgical therapy, recurrence is universal. Dysregulated DNA damage response pathway (DDR) signaling, rampant genomic instability, and radio-resistance are among the hallmarks of MGs, with current therapies only offering palliation. A subgroup of pediatric high-grade...

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PMID: 33007840
DOI: 10.3390/cancers12102813

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