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Sequence mismatch between gene-drive and target-site flanking regions significantly impairs homing efficiency in <i>Culex quinquefasciatus</i>

2025-08-01

Abstract excerpt

CRISPR/Cas9-based homing gene-drives (homing-drives) hold enormous potential as control tools for mosquito disease-vectors. These genomically-encoded technologies spread themselves through target populations by creating double-stranded DNA breaks on homologous chromosomes, into which the homing-drives are copied (‘homed’). Homing is dependent on sequence homology between the genomic regions flanking the transgene...

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Literature Corpus work
ea9e9a73-1543-5b06-a742-8b9172596c3b
DOI
10.1101/2025.08.01.668174
Open publication

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