Article

Increasing the vitamin C transporter SVCT2 in microglia improves synaptic plasticity and restrains memory impairments in Alzheimer’s disease models

2024-03-04

Abstract excerpt

Alzheimer’s Disease (AD) is characterized by progressive cognitive decline and synaptic dysfunction, often associated with amyloid-beta accumulation and microglial alterations. Here, we investigate the role of the Sodium-dependent Vitamin C Transporter 2 (SVCT2) in microglia to modulate AD-like pathology in mice. Using a combination of RNA sequencing, advanced quantitative proteomics, electrophysiology, behavioral...

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Literature Corpus work: b6790403-9438-5d5d-91a0-49e96f5ec4e0
DOI: 10.1101/2024.02.29.582679

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Increasing the vitamin C transporter SVCT2 in microglia improves synaptic plasticity and restrains memory impairments in Alzheimer’s disease modelsDOI 10.1101/2024.02.29.582679Read

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