Article
Dysregulation of Exosome Cargo by Mutant Tau Expressed in Human-induced Pluripotent Stem Cell (iPSC) Neurons Revealed by Proteomics Analyses.
Molecular & cellular proteomics : MCP - 1 Jun 2020
Podvin Sonia, Jones Alexander, Liu Qing, Aulston Brent, Ransom Linnea, Ames Janneca, Shen Gloria, Lietz Christopher B, Jiang Zhenze, O'Donoghue Anthony J, Winston Charisse, Ikezu Tsuneya, Rissman Robert A, Yuan Shauna, Hook Vivian
Abstract excerpt
Accumulation and propagation of hyperphosphorylated Tau (p-Tau) is a common neuropathological hallmark associated with neurodegeneration of Alzheimer's disease (AD), frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), and related tauopathies. Extracellular vesicles, specifically exosomes, have recently been demonstrated to participate in mediating Tau propagation in brain. Exosomes...
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