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Impact of iPSC-derived microglial exosomes on neurons: Role of TREM2 and implication in Alzheimer's Disease

2025-09-17

Abstract excerpt

<title>Abstract</title> <p>Microglial exosomes are key secretome components that modulate cell-to-cell communication mediating protective or detrimental effects depending on the environmental context upon release. The R47H variant in the microglial triggering receptor expressed on myeloid cells-2 (TREM2) increases the risk for late-onset Alzheimer’s disease (AD) and influences microglia function, contributing to...

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Literature Corpus work
41f8d088-e7e8-51bb-a549-6afccf08600c
DOI
10.21203/rs.3.rs-7487794/v1
Open publication

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