Article

Dose-dependent role of Gfi1 in murine hematopoietic stem cell self-renewal and differentiation

2019-05-07

Abstract excerpt

Gfi1 (Growth factor independence 1) is a transcription factor that influences the stem cell capacity of hematopoietic stem cells (HSCs) as well as their differentiation into the myeloid and lymphoid lineage. Loss of Gfi1 impedes the repopulation capacity of HSCs and leads to a block in granulocyte generation causing severe neutropenia and monocytosis. Competitive transplantation assays showed that Gfi1-deficient c...

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Literature Corpus work: 2d0fa073-7774-5c2c-8874-3df5eb6f6e46
DOI: 10.1101/625715

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