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Reduced expression but not deficiency of GFI1 causes a fatal myeloproliferative disease in mice

20 Jun 2018

Abstract excerpt

Growth factor independent 1 (Gfi1) controls myeloid differentiation by regulating gene expression and limits the activation of p53 by facilitating its de-methylation at Lysine 372. In human myeloid leukemia, low GFI1 levels correlate with an inferior prognosis. Here, we show that knockdown (KD) of Gfi1 in mice causes a fatal myeloproliferative disease (MPN) that could progress to leukemia after additional...

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PMID: 29925903
DOI: 10.1038/s41375-018-0166-1

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